Following his studies in organ and composition at the Giuseppe Verdi Conservatory of Music in Milan, Marcello Mottadelli started his career in 1999, as Chief Conductor of the Berner Symphoniker at the Stadttheater Bern, where he conducted: Hänsel und Gretel, Così fan Tutte, Die Fledermaus, Il Trovatore, Die Zauberflöte, Der Vogelhändler and Marta.
In 2001, he made his USA debut conducting Turandot at the Colorado Opera Company, and in the same year he also conducted “Rigoletto”, and Mahler's 2nd Symphony at the Opera of Cape Town. From 2002 to 2008, Marcello Mottadelli conducted: Der Freischütz and Rigoletto at the National Danish Opera; and symphonic concerts with the Odense and Aalborg Symphony Orchestras, the Bialystok Philharmonic Orchestra in Poland, the Orchestra Teatro Coccia in Novara in Italy, the Aarhus Symphony Orchestra in Denmark, the Slovak Radio Symphony Orchestra in Bratislava, and the Cairo Symphony Orchestra, in Egypt.
From 2008 to 2011, Marcello Mottadelli was General Music Director of the Cairo Symphony Orchestra, also making his debut in South Korea at the Seongnam Arts Centre in Seoul. In the following years, he conducted: Madama Butterfly at the Teatro Massimo in Palermo; La Bohème in Seoul; and has made several appearances with the Nürnberger Symphoniker in Germany. His recent engagements also include: Nabucco, Madama Butterfly and Andrea Chenier, as well as recordings for Bayerische Rundfunk.
From 2016 to 2017, Marcello Mottadelli was nominated Artistic and Music Coordinator of the Bucharest National Opera House, where he premiered on the Romanian stage with: Il Barbiere di Siviglia, Lucia di Lammermoor, La Traviata, Tosca and Un Ballo in Maschera.